In the Islamic economic system, it requires a thriving and growing economy in order to achieve the achievement of a public defense and the eradication of poverty from the level of society as well as the achievement of authority and economic independence. To this end, foreign affiliations should be reduced and emphasis should be placed on domestic production and efforts to self-reliance. To the point where the Supreme Leader called the resistance economy economically, which under conditions of pressure, boycott, hostility and hostility can determine the country's growth and prosperity. The purpose of this research is to identify the resistance economy in Islam and its impact on a country. This research is a descriptive-analytical method. Research suggests that an economy with a resilient economy should strive to play an influential role in the global economy, so that imposing any sanctions against the country would jeopardize global security. Based on this, the basis of the resistance economy for the Islamic Republic of Iran should be based on the Islamic economy and the principles of the Holy Quran.